There's a lot of science fiction films with adopted protagonists out there. Batman, Superman, Hellboy, Luke Skywalker. And antagonists, such as the Omen and Rosemary's Baby. As far as dramas go, not much worth remark, to me, although I'm sure there's one or two out there.
But here's my shortlist for films that to me, captured the essence of my experience, although they were not written or necessarily intended as such.
And a nod to 1987's Angel Heart, among others.